Free radical metabolites of L-cysteine oxidation.

نویسندگان

  • L S Harman
  • C Mottley
  • R P Mason
چکیده

The oxidation of L-cysteine by horseradish peroxidase in the presence of oxygen forms a thiyl free radical as demonstrated with the spin-trapping ESR technique. Reactions of this thiyl free radical result in oxygen consumption, which is inhibited by the spin trap 5,5'-dimethyl-1-pyrroline-N-oxide. Cysteine sulfinic acid, a cysteine metabolite, is a poorer substrate for horseradish peroxidase than cysteine and is oxidized to form both sulfur-centered and carbon-centered free radicals.

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عنوان ژورنال:
  • The Journal of biological chemistry

دوره 259 9  شماره 

صفحات  -

تاریخ انتشار 1984